Journal article
Increase of emm1 isolates among group A Streptococcus strains causing scarlet fever in Shanghai, China
M Chen, J Cai, MR Davies, Y Li, C Zhang, W Yao, D Kong, H Pan, X Zhang, M Zeng, M Chen
International Journal of Infectious Diseases | ELSEVIER SCI LTD | Published : 2020
Abstract
Objective: Scarlet fever epidemics caused by group A Streptococcus (GAS) have been ongoing in China since 2011. However, limited data are available on the dynamic molecular characterizations of the epidemic strains. Method: Epidemiological data of scarlet fever in Shanghai were obtained from the National Notifiable Infectious Disease Surveillance System. Throat swabs of patients with scarlet fever and asymptomatic school-age children were cultured. Illumina sequencing was performed on 39emm1 isolates. Results: The annual incidence of scarlet fever was 7.5–19.4/100,000 persons in Shanghai during 2011–2015, with an average GAS carriage rate being 7.6% in school-age children. The proportion ofe..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was supported by the grants from Key project funded by Shanghai Municipal Commission of Health and Family Planning (201640002), National Natural Science Foundation of China (81601801), Shanghai Rising-Star Program (17QA1403100), a Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai (2017YQ039), the 13th Five-Year Project of National Health and Family Planning Commission of the People's Republic of China (2017ZX10303405-004 and 2017ZX10103009-003), and the National Health and Medical Research Council of Australia project grant (1126805). MRD is supported by a University of Melbourne CR Roper Fellowship. The fundershadnoroleinstudydesign, datacollection, andinterpretation, or the decision to submit the work for publication.